In recent years, different processing technologies have been engineered to fabricate\ncapsules or particles with peculiar properties (e.g., swelling, pH-sensitive response) at the micro\nand sub-micrometric size scale, to be used as carriers for controlled drug and molecular\nrelease. Herein, the development of cellulose acetate (CA) micro-carriers with mono- (MC)\nor bi-phasic (BC) composition is proposed, fabricated via electrohydrodynamic atomization\n(EHDA)- an electro-dropping technology able to micro-size polymer solution by the application of\nhigh voltage electrostatic forces. Image analysis allows identification of the process parameters to\noptimize morphology, in terms of size distribution and shape. Meanwhile, an accurate rheological\nstudy has enabled investigating the interface between CA solutions with different viscosities to\noptimize BC systems. Release tests have confirmed that BC carriers can retain the drug more efficiently\nin acidic conditions, also providing a more gradual and sustained release until six days, with respect\nto MC carriers. Hence, all these results have proven that biphasic architecture significantly improves\nthe capability of CA microcarriers to release ketoprofen lysinate, thus suggesting a new route to\ndesign core/shell systems for the retarded oral administration of anti-inflammatory drugs.
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